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Establishment of vaginal immune defenses at the mucosal interface layer through gene vaccines promise to prevent infectious diseases among females. Mucosal barriers composed of a flowing mucus hydrogel and tightly conjugated epithelial cells (ECs), which represent the main technical difficulties for vaccine development, reside in the harsh, acidic human vaginal environment. Different from frequently employed viral vectors, two types of nonviral nanocarriers were designed to concurrently overcome the barriers and induce immune responses. Differing design concepts include the charge-reversal property (DRLS) to mimic a virus that uses any cells as factories, as well as the addition of a hyaluronic acid coating (HA/RLS) to directly target dendritic cells (DCs). With a suitable size and electrostatic neutrality, these two nanoparticles penetrate a mucus hydrogel with similar diffusivity. The DRLS system expressed a higher level of the carried human papillomavirus type 16 L1 gene compared to HA/RLS in vivo. Therefore it induced more robust mucosal, cellular, and humoral immune responses. Moreover, the DLRS applied to intravaginal immunization induced high IgA levels compared with intramuscularly injected DNA (naked), indicating timely protection against pathogens at the mucus layer. These findings also offer important approaches for the design and fabrication of nonviral gene vaccines in other mucosal systems.
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Objective To understand the current overall status of implementation on the National Demonstration Areas of Comprehensive Prevention and Control of Non-communicable Diseases.Methods According to the scheme design of the questionnaires,all the National Demonstration Areas were involved in this study.For each National Demonstration Areas,eight departments were selected to complete a total of 12 questionnaires.Results Scores related to the implementation of the National Demonstration Areas accounted for 71.8％ of the total 170 points.Based on the scores gathered from this study,the 23-items-index-system that represented the status of project implementation was classified into seven categories.Categories with higher percentile scores would include:monitoring (88.0％),safeguard measures (75.0％),health education and health promotion (75.0％).Categories with lower percentile scores would include:the national health lifestyle actions (67.7％),community diagnosis (66.7％),discovery and intervention of high-risk groups (64.7％),and patient management (60.9％).There were significant differences noticed among the eastern,central and western areas on items as safeguard measures,health education/promotion,discovery and intervention of high-risk groups.In all,the implementation programs in the eastern Demonstration Areas seemed better than in the central or western regions.As for the 23 items,five of the highest scores appeared on policy support,mortality surveillance,tumor registration,reporting system on cardiovascular/cerebrovascular events,and on tobacco control,respectively.However,the lowest five scores fell on healthy diet,patient self-management program,oral hygiene,setting up the demonstration units and promotion on basic public health services,respectively.The overall scores in the eastern region was higher than that in the central or the western regions.The scores in the central and western regions showed basically the same.Conclusions The overall status of implementation on the National Demonstration Areas was satisfactory.Future attention should be focusing on patient management as well as discovery and intervention of high-risk groups,which also presented the lowest scores,in this survey.
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Objective To investigate the consumption of vegetables and fruits and related influencing factors among residents from the National Demonstration Areas of Comprehensive Prevention and Control of Non-communicable Diseases.Methods From November to December,2016,a total of 4 000 residents,aged 18 or above,from ten Demonstration Areas,were selected as participants for this study by multi-stage cluster random sampling method.Information on vegetables,fruits consumption and related influencing factors was collected via questionnaire.Results A total of 3 891 residents were involved in the final analysis.Daily consumption of vegetables and fruits accounted for 72.1％ and 53.6％ of the residents under study.The residents who were aware of the National Demonstration Areas activities were more willing to have adequate intake of vegetables (OR=3.017,95％CI:2.426-3.753) and fruits (OR=1.261,95％CI:1.007-1.580).Residents with higher degree of participation activities of the demonstration areas were more likely to have adequate fruits intake (high degree:OR=1.431,95％CI:1.210-1.694;medium degree:OR=1.573,95％CI:1.315-1.882).Conclusions The implementation of the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases has improved the adequate vegetables and fruits intake among residents.Relevant activities carried out in the Demonstration Areas appeared conducive to the healthy lifestyle of the residents.
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Objective To understand the current situation on management of diabetes mellitus patients aged 35 and above in the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases,in China.Methods Local residents,aged 18 years and above were randomly selected by a complex,multistage,probability sampling method.Face-to-face questionnaire survey was carried out between November and December 2016.Rates regarding prevalence,treatment and management of diabetes were calculated,and influencing factors of diabetes were analyzed by using the non-conditional logistic regression model.Results A total of 3 213 residents aged ≥35 years were included in this study,of which 11.48％ (369/3 213) reported that they had ever been informed by a doctor or other health worker that their blood sugar level was high or being diabetic.The rate of self-reported treatment among the diabetic patients was 83.20％ (307/369).Rates on overall management and standardized management were 69.92％ (258/369) and 53.66％ (198/369),respectively.Higher rates were seen in residents aged 55 to 64 years,76.32％ for overall management and 59.65％ for standardized management.Through multiple logistic regression analysis,we found that standardized management for diabetes was much higher in the Demonstration Areas located in the eastern areas (OR=2.942,95％CI:1.547-5.594),or patients with characteristics including high implementation score (OR=3.499,95％ CI:1.865-6.563),already signed family doctors (OR=5.661,95％ CI:3.237-9.899),or without hypertension (OR=1.717,95％ CI:1.010-2.920).Residents who were living in the first and second batch areas of implementation or responding to the NCDs with positive attitude were more likely to accept standardized management.Conclusion Prevention and management programs on diabetes had met the requirements set for the Demonstration Areas which had promoted the specific implementation and further development of standardized management on diabetes.
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Objective To investigate the current status of prevalence,treatment,and management on hypertension among Chinese adults from the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases.Methods We selected a total of 4 000 residents aged ≥ 18 years for this questionnaire-based survey by multi-stage clustering sampling in 10 National Demonstration Areas between November and December,2016.Results There were 3 891 effective questionnaires.The self-reported prevalence of hypertension among aged ≥35 years was 31.47％ (1 011/3 213).For the past two weeks,the self-reported treatment of hypertension was 86.75％(877/1 011),with the rates of guidance as 56.87％ (575/1 011) on physical activity,40.95％ (414/1 011) on diet,38.33％ (385/1 011) on weight management,and 22.75％ (228/1 011) on smoking cessation.For the past 12 months,74.68％ (755/1 011) of the residents aged ≥35 years were under the proper management and 62.12％ (628/1 011) of them were under the standardized management programs.The follow-up program lasted for 4 (P2s-P75:4-12) times per year,with 15 (P25-P75:10-20)minutes per each visit.Hypertensive patients would mainly visit the outpatient clinics (53.51％),followed by home visits (22.91％) and telephone calls (13.64％).Rate of satisfaction on management services was 94.83％ (716/755) from the hypertensive patients.Multivariate analysis showed that the rate of self-reported treatment (OR=1.986,95％ CI:1.222-3.228) and self-reported standardized management (OR=2.204,95％CI:1.519-3.199) on hypertension were higher in the Demonstration Areas with higher implementation scores of self-reported non-communicable diseases management.Conclusions Prevention and management on hypertension in the Demonstration Areas had met the requirement set for the Demonstration Areas during the "12th Five-Year Plan".Projects on setting up the National Non-communicable Diseases Demonstration Areas had played an active role in promoting the standardized management program on hypertension.
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Objective To assess the implementation and impact of programs carried out by the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases.Methods Both sociological and epidemiological methods were used to collect qualitative and quantitative data in November and December,2016 in order to conduct on process and outcome evaluation of the above mentioned objective.In the meantime,case study was also conducted.Results All the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases were found well implemented across the country,with health education and health promotion,surveillance and safeguard measures in particular.A government-led and inter-sector coordination and communication mechanism had been well established,with more than 16 non-health departments actively involved.28.7％ of the residents living in the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases were aware of the key messages related to chronic diseases.Among the residents,72.1％ of them consumed vegetables and 53.6％ consumed fruits daily,with another 86.9％ walked at least 10 minutes per day.Over 70％ of the patients with hypertension or diabetes reported that they were taken care of by the Community Health Centers,and above 50％ of them were under standardized management.Residents,living in the National Demonstration Areas under higher ranking of implementation scores,were more likely to be aware of relevant knowledge on chronic disease control and prevention (OR=6.591,95％CI:5.188-8.373),salt reduction (OR=1.352,95％CI:1.151-1.589),oil reduction (OR=1.477,95％CI:1.249-1.746) and recommendation on physical activities (OR =1.975,95％ CI:1.623-2.403).Conclusion The implementation of programs carried out by the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases had served a local platform for the control and prevention of non-communicable diseases,and thus become an important'carrier'for chronic disease prevention and control programs in China.
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Objective To understand the current overall status of implementation on the National Demonstration Areas of Comprehensive Prevention and Control of Non-communicable Diseases.Methods According to the scheme design of the questionnaires,all the National Demonstration Areas were involved in this study.For each National Demonstration Areas,eight departments were selected to complete a total of 12 questionnaires.Results Scores related to the implementation of the National Demonstration Areas accounted for 71.8％ of the total 170 points.Based on the scores gathered from this study,the 23-items-index-system that represented the status of project implementation was classified into seven categories.Categories with higher percentile scores would include:monitoring (88.0％),safeguard measures (75.0％),health education and health promotion (75.0％).Categories with lower percentile scores would include:the national health lifestyle actions (67.7％),community diagnosis (66.7％),discovery and intervention of high-risk groups (64.7％),and patient management (60.9％).There were significant differences noticed among the eastern,central and western areas on items as safeguard measures,health education/promotion,discovery and intervention of high-risk groups.In all,the implementation programs in the eastern Demonstration Areas seemed better than in the central or western regions.As for the 23 items,five of the highest scores appeared on policy support,mortality surveillance,tumor registration,reporting system on cardiovascular/cerebrovascular events,and on tobacco control,respectively.However,the lowest five scores fell on healthy diet,patient self-management program,oral hygiene,setting up the demonstration units and promotion on basic public health services,respectively.The overall scores in the eastern region was higher than that in the central or the western regions.The scores in the central and western regions showed basically the same.Conclusions The overall status of implementation on the National Demonstration Areas was satisfactory.Future attention should be focusing on patient management as well as discovery and intervention of high-risk groups,which also presented the lowest scores,in this survey.
ABSTRACT
Objective To investigate the consumption of vegetables and fruits and related influencing factors among residents from the National Demonstration Areas of Comprehensive Prevention and Control of Non-communicable Diseases.Methods From November to December,2016,a total of 4 000 residents,aged 18 or above,from ten Demonstration Areas,were selected as participants for this study by multi-stage cluster random sampling method.Information on vegetables,fruits consumption and related influencing factors was collected via questionnaire.Results A total of 3 891 residents were involved in the final analysis.Daily consumption of vegetables and fruits accounted for 72.1％ and 53.6％ of the residents under study.The residents who were aware of the National Demonstration Areas activities were more willing to have adequate intake of vegetables (OR=3.017,95％CI:2.426-3.753) and fruits (OR=1.261,95％CI:1.007-1.580).Residents with higher degree of participation activities of the demonstration areas were more likely to have adequate fruits intake (high degree:OR=1.431,95％CI:1.210-1.694;medium degree:OR=1.573,95％CI:1.315-1.882).Conclusions The implementation of the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases has improved the adequate vegetables and fruits intake among residents.Relevant activities carried out in the Demonstration Areas appeared conducive to the healthy lifestyle of the residents.
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Objective To understand the current situation on management of diabetes mellitus patients aged 35 and above in the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases,in China.Methods Local residents,aged 18 years and above were randomly selected by a complex,multistage,probability sampling method.Face-to-face questionnaire survey was carried out between November and December 2016.Rates regarding prevalence,treatment and management of diabetes were calculated,and influencing factors of diabetes were analyzed by using the non-conditional logistic regression model.Results A total of 3 213 residents aged ≥35 years were included in this study,of which 11.48％ (369/3 213) reported that they had ever been informed by a doctor or other health worker that their blood sugar level was high or being diabetic.The rate of self-reported treatment among the diabetic patients was 83.20％ (307/369).Rates on overall management and standardized management were 69.92％ (258/369) and 53.66％ (198/369),respectively.Higher rates were seen in residents aged 55 to 64 years,76.32％ for overall management and 59.65％ for standardized management.Through multiple logistic regression analysis,we found that standardized management for diabetes was much higher in the Demonstration Areas located in the eastern areas (OR=2.942,95％CI:1.547-5.594),or patients with characteristics including high implementation score (OR=3.499,95％ CI:1.865-6.563),already signed family doctors (OR=5.661,95％ CI:3.237-9.899),or without hypertension (OR=1.717,95％ CI:1.010-2.920).Residents who were living in the first and second batch areas of implementation or responding to the NCDs with positive attitude were more likely to accept standardized management.Conclusion Prevention and management programs on diabetes had met the requirements set for the Demonstration Areas which had promoted the specific implementation and further development of standardized management on diabetes.
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Objective To investigate the current status of prevalence,treatment,and management on hypertension among Chinese adults from the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases.Methods We selected a total of 4 000 residents aged ≥ 18 years for this questionnaire-based survey by multi-stage clustering sampling in 10 National Demonstration Areas between November and December,2016.Results There were 3 891 effective questionnaires.The self-reported prevalence of hypertension among aged ≥35 years was 31.47％ (1 011/3 213).For the past two weeks,the self-reported treatment of hypertension was 86.75％(877/1 011),with the rates of guidance as 56.87％ (575/1 011) on physical activity,40.95％ (414/1 011) on diet,38.33％ (385/1 011) on weight management,and 22.75％ (228/1 011) on smoking cessation.For the past 12 months,74.68％ (755/1 011) of the residents aged ≥35 years were under the proper management and 62.12％ (628/1 011) of them were under the standardized management programs.The follow-up program lasted for 4 (P2s-P75:4-12) times per year,with 15 (P25-P75:10-20)minutes per each visit.Hypertensive patients would mainly visit the outpatient clinics (53.51％),followed by home visits (22.91％) and telephone calls (13.64％).Rate of satisfaction on management services was 94.83％ (716/755) from the hypertensive patients.Multivariate analysis showed that the rate of self-reported treatment (OR=1.986,95％ CI:1.222-3.228) and self-reported standardized management (OR=2.204,95％CI:1.519-3.199) on hypertension were higher in the Demonstration Areas with higher implementation scores of self-reported non-communicable diseases management.Conclusions Prevention and management on hypertension in the Demonstration Areas had met the requirement set for the Demonstration Areas during the "12th Five-Year Plan".Projects on setting up the National Non-communicable Diseases Demonstration Areas had played an active role in promoting the standardized management program on hypertension.
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Objective To assess the implementation and impact of programs carried out by the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases.Methods Both sociological and epidemiological methods were used to collect qualitative and quantitative data in November and December,2016 in order to conduct on process and outcome evaluation of the above mentioned objective.In the meantime,case study was also conducted.Results All the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases were found well implemented across the country,with health education and health promotion,surveillance and safeguard measures in particular.A government-led and inter-sector coordination and communication mechanism had been well established,with more than 16 non-health departments actively involved.28.7％ of the residents living in the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases were aware of the key messages related to chronic diseases.Among the residents,72.1％ of them consumed vegetables and 53.6％ consumed fruits daily,with another 86.9％ walked at least 10 minutes per day.Over 70％ of the patients with hypertension or diabetes reported that they were taken care of by the Community Health Centers,and above 50％ of them were under standardized management.Residents,living in the National Demonstration Areas under higher ranking of implementation scores,were more likely to be aware of relevant knowledge on chronic disease control and prevention (OR=6.591,95％CI:5.188-8.373),salt reduction (OR=1.352,95％CI:1.151-1.589),oil reduction (OR=1.477,95％CI:1.249-1.746) and recommendation on physical activities (OR =1.975,95％ CI:1.623-2.403).Conclusion The implementation of programs carried out by the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases had served a local platform for the control and prevention of non-communicable diseases,and thus become an important'carrier'for chronic disease prevention and control programs in China.
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Objective To access the current status of folic acid supplementation in women at childbearing age in suburban area of Beijing,2016.Methods In this cross-sectional study,a total of 722 women aged 17-41 years from six hospitals in suburban areas of Beijing were selected through cluster sampling.A questionnaire survey was conducted.Results The rates of folic acid intake and regular folic acid intake among women under survey were 63.9％ (456/714) and 83.3％ (380/456).In women who remembered the duration of folic acid supplementation,the overall rate of preconceptional folic acid supplementation was 35.5％ (159/450),in whom 27.3％ (123/450) began to take folic acid 0-3 months before pregnancy;8.0％ (36/450) began to take folic acid 3 months before pregnancy.Multivariate logistic regression analysis indicated that household registering type,preparation for pregnancy or pregnancy,parity,smoking and alcohol use were the influencing factors for folic acid supplementation.Conclusions The rate of folic acid supplementation remained low in childbearing aged women in suburban area of Beijing.It is necessary to further strengthen the health education about the importance of folic acid supplementation to improve the intake rate and the regular intake rate of folic acid in pregnant women and to promote maternal infant health and reduce the related complications.
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Objective To analyze the association between pesticide exposure and adverse pregnancy outcomes in women from the rural areas of China.Methods Data of "National Free Preconception Health Examination Project (NFPHEP)" from January 2010 to December 2012 was used for analysis.A total of 248 501 families that were planning to deliver a baby in the next 6 months were enrolled.Data on paternal exposure to pesticides before or during pregnancy was collected through questionnaires,with related outcomes on pregnancy recorded by doctors.Results Among all the 248 501 participants,1 806 (0.74％) women and 2 653 (1.09％) men reported to have been exposed to pesticide before pregnancy,with 505 (0.21％) reported of having been exposed to pesticide during the period of pregnancy.Maternal exposure to pesticide was found a risk factor related to stillbirth (OR=3.37,95 ％ CI:2.05-5.55),peculiar smell pregnancy (OR =3.17,95％CI:1.18-8.55) and low birth weight (OR=7.56,95％ CI:5.36-10.66).Paternal exposure to pesticide was also found related to miscarriage (OR=1.37,95％ CI:1.03-1.80),low birth weight (OR=3.65,95％ CI:1.51-8.84),or giant infant (OR?=0.64,95％ CI:0.44-0.93).Maternal exposure to pesticide during pregnancy appeared a risk factor on miscarriage (OR=4.65,95％ CI:3.47-6.24).Other adverse outcomes on pregnancy would include premature birth and high birth weight.Conclusion Parental pesticide exposure appeared a risk factor on stillbirth,peculiar smell pregnancy,low birth weight and miscarriage.
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Objective@#To evaluate the relationship between visceral pleural invasion (VPI) and other clinicopathological features in lung adenocarcinoma with tumor size ≤3 cm, and to investigate the impact of VPI on the patients′ prognosis.@*Methods@#The clinical and pathological features were retrospectively reviewed in 231 cases of lung adenocarcinoma with the largest diameter of tumor ≤3 cm, following complete resection and systemic lymphadenectomy. VPI was divided into three grades, PL0, PL1 and PL2 according to modified Hammar classification for lung cancer upon elastic fiber staining. Survival analysis was performed by Kaplan-Meier method, and the risk factors for prognosis were explored by Cox proportional hazards model. Patient prognosis was evaluated by progression-free survival (PFS) and overall survival (OS).@*Results@#In all 231 cases, the number of patients with VPI was 70 (30.3%), of which 61 cases were PL1 and 9 cases were PL2. The remaining 161 cases (69.7%) had no VPI (PL0). The tumor size (P=0.003), histological grade (P<0.01), the presence of solid component (P=0.001) and micropapillary component (P=0.009), N stage (P<0.01) and TNM stage (P<0.01) were significantly correlated with VPI. Patients with VPI had significantly shorter PFS and OS than those without VPI (P<0.01). There were significant differences in PFS and OS between patients with different VPI levels (P<0.01). Cox multivariate regression analysis showed that VPI was not an independent prognostic factor, whereas PL2 was an independent prognostic factor for PFS (P=0.007), but not an independent prognostic factor for OS (P=0.052).@*Conclusions@#For patients with lung adenocarcinoma of tumor size ≤3 cm, VPI is related to poor prognosis; However, only PL2 is an independent prognostic factor for PFS. It may be not necessary to separate PL0 and PL1 status in smaller lung adenocarcinomas. Therefore, the definition of VPI may need further modification through large cohort studies.
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Objective@#To investigate the clinical value of p16/Ki-67 immunocytochemistry in patients with atypical squamous cells of undetermined significance(ASC-US).@*Methods@#One hundred and seventy-one cases of thin-prep cytology test (TCT) diagnosed as ASC-US underwent p16/Ki-67 immunocytochemistry. All patients had colposcopy and biopsy from March 2015 to January 2016. Ninety of the 171 cases underwent high-risk HPV test at the same time.@*Results@#p16/Ki-67 immunocytochemistry was positive in 43.9% (75/171) of the 171 cytology samples; the sensitivity and specificity of p16/Ki-67 immunocytochemistry were 77.6%(52/67) and 77.9%(81/104) in detecting CIN2+ , and the positive and negative predictive value were 69.3%(52/75) and 84.4%(81/96), respectively. The sensitivity and specificity in diagnosing CIN2+ were 100.0%(34/34) and 10.7%(6/56) for HPV test, and the positive and negative predictive value were 40.5%(34/84) and 6/6. p16/Ki-67 immunocytochemistry showed lower sensitivity but obviously higher specificity than high-risk HPV detection.@*Conclusion@#p16/Ki-67 immunocytochemistry is a good triage test for identifying CIN2+ in ASC-US specimens.
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Objective To access the current status of folic acid supplementation in women at childbearing age in suburban area of Beijing,2016.Methods In this cross-sectional study,a total of 722 women aged 17-41 years from six hospitals in suburban areas of Beijing were selected through cluster sampling.A questionnaire survey was conducted.Results The rates of folic acid intake and regular folic acid intake among women under survey were 63.9％ (456/714) and 83.3％ (380/456).In women who remembered the duration of folic acid supplementation,the overall rate of preconceptional folic acid supplementation was 35.5％ (159/450),in whom 27.3％ (123/450) began to take folic acid 0-3 months before pregnancy;8.0％ (36/450) began to take folic acid 3 months before pregnancy.Multivariate logistic regression analysis indicated that household registering type,preparation for pregnancy or pregnancy,parity,smoking and alcohol use were the influencing factors for folic acid supplementation.Conclusions The rate of folic acid supplementation remained low in childbearing aged women in suburban area of Beijing.It is necessary to further strengthen the health education about the importance of folic acid supplementation to improve the intake rate and the regular intake rate of folic acid in pregnant women and to promote maternal infant health and reduce the related complications.
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Objective To analyze the association between pesticide exposure and adverse pregnancy outcomes in women from the rural areas of China.Methods Data of "National Free Preconception Health Examination Project (NFPHEP)" from January 2010 to December 2012 was used for analysis.A total of 248 501 families that were planning to deliver a baby in the next 6 months were enrolled.Data on paternal exposure to pesticides before or during pregnancy was collected through questionnaires,with related outcomes on pregnancy recorded by doctors.Results Among all the 248 501 participants,1 806 (0.74％) women and 2 653 (1.09％) men reported to have been exposed to pesticide before pregnancy,with 505 (0.21％) reported of having been exposed to pesticide during the period of pregnancy.Maternal exposure to pesticide was found a risk factor related to stillbirth (OR=3.37,95 ％ CI:2.05-5.55),peculiar smell pregnancy (OR =3.17,95％CI:1.18-8.55) and low birth weight (OR=7.56,95％ CI:5.36-10.66).Paternal exposure to pesticide was also found related to miscarriage (OR=1.37,95％ CI:1.03-1.80),low birth weight (OR=3.65,95％ CI:1.51-8.84),or giant infant (OR?=0.64,95％ CI:0.44-0.93).Maternal exposure to pesticide during pregnancy appeared a risk factor on miscarriage (OR=4.65,95％ CI:3.47-6.24).Other adverse outcomes on pregnancy would include premature birth and high birth weight.Conclusion Parental pesticide exposure appeared a risk factor on stillbirth,peculiar smell pregnancy,low birth weight and miscarriage.
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Through literature study,this paper summarizes the current status ofreseareh on the relationship between maternal exposure factors and small for gestational age infant both in China and abroad.And at the same time,the relationship between pregnancy outcome of small for gestational age and maternal exposure factors was analyzed.This might contribute to reduce the incidence of small for gestational age infant and provide important guidance and references for perinatal care.
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Objective To analyze the cognition and demand of the residency training program among clinical medical students to provide scientific basis for the promotion of this policy.Methods From May 24 to 25,2015,a self-designed questionnaire survey was conducted on 645 undergraduate clinical medical students,who came from Zhengzhou University,Xinxiang Medicine College,Henan University.Data of cognition and demand of the residency standardized training were statistically analyzed using SPSS 22.0 software.Enumeration data were analyzed by chi-square test and abnormal distribution data based on Wilcoxon rank sum test.Results 616 valid questionnaires were recovered.259 undergraduate clinical medical students (42.00％) did not quite understand the resident standardized training policy and 225 (36.50％) did not known the policy at all.Before and after clinical practice,the cognition of the residency standardized training had statistically significant difference (x2=87.596,P=0.000),the knowledge of the policy (x2=10.939,P=0.012) and the degree ascending alleviate employment pressure (x2=29.349,P=0.000) were the main influencing factors of the clinical medical students' choices after graduation.Conclusion Improving medical students' understanding of the significance of medical education after graduation,and the integration of professional degree training and residency standardization training effectively helps to promote implementation of the policy.
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Through literature study,this paper summarizes the current status ofreseareh on the relationship between maternal exposure factors and small for gestational age infant both in China and abroad.And at the same time,the relationship between pregnancy outcome of small for gestational age and maternal exposure factors was analyzed.This might contribute to reduce the incidence of small for gestational age infant and provide important guidance and references for perinatal care.